Autoimmunity/Inflammation - Immune Regulation

Inflammation is an essential defence mechanism of our immune system to fight pathogens and to attack malignant tissues. However, inflammatory conditions can become harmful if not properly controlled or if inflammatory processes are engaged against self (autoimmunity). While inflammation is a multifactor process involving soluble and cellular components, very often, a single deregulated master-cytokine can lead to the pathological exacerbation of an inflammatory condition. One well-characterized cytokine, TNFα, is a prime example of a master-cytokine that upon targeting can lead to a significant improvement of autoimmune and inflammatory conditions.

We have developed fully human antibodies against another well-characterized pro-inflammatory cytokine that has the potential to be as important in regulation of inflammation as TNFα.

While antibodies against this factor have been developed in the past, we believe that the existing products and product candidates have some limitations that our product candidates could overcome.

Our product candidate is currently still in lead optimization and we have not yet disclosed the molecular target.